maxxipaws maxxiSAMe SAM-e Powder for Dogs - Liver & Cognitive Support 150g

MIRACLE PRODUCT!! This in my opinion is the two words that sum up this product; the results to me have been astounding, and I truly do believe this product has saved my dog (Shankly’s) life. I have attached photos from his blood tests prior to have his supplements and his blood test 7 weeks later, after having 7 weeks worth of supplements, just so you can see the difference!! This is going to be a very in-depth review, so please bear with me on this. So in a nutshell and a quick brief on my dogs background/medical history; he is on steroids for the rest of his life due to a medical condition known in short as MMM, basically this is where his immune system attacked his jaw and head muscles and caused severe and excruciating painful inflammation, in order for this condition to be kept at bay he requires steroids for the rest of his life. Obviously steroids are known to be very hard on the liver long term, we monitor his bloods regularly, and unfortunately his liver was showing signs of strain on his last blood test, so we were advised to put him on liver supplements. He did have bloods done a month and half prior to this and all was ok, but I felt something wasn’t quite right with him as he appeared tired all the time, to the point he looked shattered, and was showing less enthusiasm on his walks, so I went in with a full blood panel at the vets, and this is when we received news that his liver was showing signs of strain. The vet recommended Samylin, which we were willing to put him on, this would cost us £140 per month for him to be placed on these supplements. I wanted to source a more natural alternative if possible, and hopefully something what was more affordable. I come across this product on Amazon, read all the reviews and looked at the ingredients in MaxxiSAMe to see how they compared to Samylin. I gave MaxxiPaws a call, they were absolutely fantastic; I was obviously very upset when I called due to blood test results, the lady on the phone was able to calm me down, she listened to what I had to say without rushing me and explained about the MaxxiSAMe product, they also emailed me information about their product and FAQ’s, and hints and tips on how to administer the supplement powder. I obviously sent the information the MaxxiPaws team sent me, across to my vet, who confirmed it contained the same as the (expensive) Samylin, alongside extra added vitamins and said this would be ok to place Shankly on. The only difference the vet stated, is that silybin/silymarin component comes from the artichoke plant, as opposed to the milk thistle plant. But looking into this myself, and also in discussing this with the MaxxiPaws team, the artichoke is the better source for the silybin/silymarin to come from. The dosage for the main components that is used in the MaxxiSAMe, is the same as the Samylin therefore you are getting the exact same product as what the vet prescribed, but at a fraction of the cost, and you also get the added benefits of the extra vitamins, so you get a lot more bang for your buck. Within a couple of days of Shankly taking the supplement I noticed he appeared to be getting more energy, although it was very subtle at this stage, he seemed to be awake more and have more pep in his step, by day 3, his increase in energy levels were more noticeable, and more people were noticing this, not just myself. This made me super happy and was an absolute joy to see! I thought something must be moving in the right direction due to what I am seeing, his movements were a lot quicker, he was running up and down the stairs a lot quicker, jumping in the car a lot quicker, showing more enthusiasm when asking if he wanted to go on a walk, and also wasn’t laying down immediately after a walk. I would say after 3 weeks his energy levels were what they had been prior to his liver being under strain, at this point, me and my husband were feeling quietly confident that his next set of bloods would show improvement. The MaxxiPaws team were also optimistic to, as they said this is one of the first things a lot of owners noticed when they first gave their dog the supplement, the increase in energy levels. Shankly’s bilirubin levels, and bile acids were the main concern, as they were tittering on the edge of the ‘safe parameters’, although they were out of the normal range, his bilirubin was three times higher than what it should have been. He has been on this supplement for 6 and half weeks, to be precise, and on the recent blood test, his bilirubin was back in the normal parameters, as was his bile acids levels, and the rest of the liver enzymes! I was shocked, at how well his body has taken the supplement, I knew we would see a decrease in the enzyme levels, but not this much. It’s pretty amazing in such a short time frame his liver is operating healthily now and not showing signs of strain, I was absolutely over the moon with the results, and how much this has helped my boy. I cried with relief when we got those results in, and with tears of joy and happiness. This for me, is nothing short of a miracle, I honestly can’t thank the company MaxxiPaws enough for what their product has done for my dog, I truly believe they have saved his life. Not only that, but the support MaxxiPaws have provided me throughout these past 7 weeks has been phenomenal, I have been a nervous wreck due to worrying about my dog and his liver enzymes, the MaxxiPaws team have been there to support me every step of the way, allowing me to keep my anxiety under control and helping me to remain more optimistic. I have regularly kept in contact with them, to update them on Shanklys progress; they are always very happy to hear how well Shankly has been doing, and always get back to me. I wish more companies had the response to their customers that MaxxiPaws have; their customer service is impeccable, you really do feel, and know, that they are pet owners themselves and they take great pride and care in everything they do, they are such genuinely nice and caring people who’re keen to help your pet, and also to support you as an owner, through a tough time (as I found dealing with the liver enzyme issues of Shankly, very worrying and upsetting). It’s just so rare especially in the pet industry where you come across such an amazing company and a team of people (MaxxiPaws), who care as much as they do! For that I am truly, truly grateful, so much so that I feel words cannot express how grateful I am to them. Back on to the supplement, it is in powder form, which makes it fantastic to mix in with food. Shankly has his kibble soaked, and I add a quarter of a can of tuna in spring water and mix into a small portion of his kibble, to ensure he eats it all. He was a bit fussy at first, as dogs can be with new tasting things, but we got it down him, and this product works wonderfully, which is the main thing. Once he’s eaten this portion the rest of his meal is then placed down. The supplement comes with a scoop, allowing you to measure out the portion, and they recommend this is split between two meals, which we have been doing. His dose was double for the first few weeks, to help give his liver a good boost, and then the dose reduced a little bit more, and currently, 6 weeks in, he is on the maintenance dose. The MaxxiPaws team helped me with the support of what dose to place him on and then when to reduce it, as I just wanted to be sure that everything I was doing was correct and his liver was receiving the best support possible. Shankly weighs 27kg so using his maintenance dose of MaxxiSAMe, the tub lasts approximately a month. Shankly will remain on this supplement for the rest of his life, but I am perfectly fine with that, it’s all natural, which is fantastic for him and allows me to use the product with more confidence. I feel confident that all will be well now with Shankly and the continued use of supplements alongside his current medication which he has to have. I order mainly now, through their website, my first order was placed via Amazon as that’s where I initially saw the product, but, I have since joined the ‘MaxxiClub’ and receive a discount on any products I order through their website, you are also entered into a draw when you join the MaxxiClub, so you get a chance to win a free product in their draw, which is another perk. They donate to charities also, on a monthly basis, which is such a great thing for them to do as company, as I doubt many other companies have such kind gestures. Would I recommend this product to anybody whose dog has liver issues?! You bet I would. This product to my dog, has been a life saver, the results showing in his recent blood works are fantastic! I would without a shadow of a doubt recommend this product to any dog who needs it, I would also confidently use any of MaxxiPaws products on my dog if needs be, as I have that much confidence in their products and the company. April Update 2026 - My dogs blood tests come back as very good again, so happy that the product is continuing to do the good work.

Our eldest dachshund had a very high liver enzyme count when bloods were taken, following major gastric surgery. Our vet recommended a tablet that contained various ingredients to support the liver. The tablet brought his enzymes down, but, it is very expensive for a months supply, and on some days I would find the soggy tablet later in the day hidden near the fridge freezer. Reading reviews online, I became aware of several customers who had similar issues , and had tried the Maxxi SAMe instead with great results. Had a good read up, the SAMe quantity was identical, with silybjn too, from a different source, but also several other excellent ingredients , such as vitamin B12, B6, B1, B2 inositol, and choline. These are very important for nervous system and brain function. Plus the fact , that the tub is very generous for the money. So you get more benefit for a far more resonable cost . My dog has 1/4 scoop twice a day ,which is 1.25 gms for his weight of 6.6 kg. I purchased this tub in March and will need my next tub in July . The final clincher for this product, is the advice and customer service from the manufacturer. They have a great website with a dedicated phone line. When I phoned to discuss withholding Maxxi Cardio for a few days before his dental surgery, they were extremely knowledgeable and helpful. It's unusual, in my experience, to find people so invested in getting products that benefit pets. This is possibly because they all are pet owners and use these products themselves. I also had a very nice follow up email regarding dosage of Maxxi Joint for my younger dachshund. Milo had routine bloods taken before his dental in May, since he is almost 15 and surgery not without risk . Our vet stated that for his age, the bloods were good, and liver enzymes are now only mildly elevated, which is as expected for his age and pancreatic issues. Our vet was even more impressed with his recovery at his 10 day post op check , as were we. He is a different dog and I am convinced that introducing Maxxi Cardio (which I have also reviewed) was crucial to his well being as he had become quite weak with a heart murmur. If you are tempted to try the Maxxi Paws products, then contact with the customer service will no doubt help your decision, and give you good guidance. For us , Maxxi Same and Maxxi Cardio play a big part in our dachshund's fantastic health, and have hugely improve his quality of life .

Replaced instead of a tablet version and so far no issues.

Just about to order my 3rd tub. My border collie was diagnosed last year with liver cancer, which was causing her pancreas and kidney levels to become very elevated. She had very sloppy stools and was going 4 times a day. Within a couple of days of giving her this supplement I noticed a big improvement in the quality of what was coming out of her rear end; also the number and size of stools reduced. Additionally, she had been looking very dozy and is much more her lively self now. I cannot comment on whether or not it has reduced her liver count as this is no longer being tested. You may find that, to get results, you do not need as much as it says on the container. I give her one scoop a day, which is less than what is suggested, and the tub lasts 3 months. To reply to some comments in other reviews. The powder is a bit bitter (I tried it myself) but my dog happily eats it in her food spread over 4 meals a day. I do mix it in well. I don't find it goes lumpy, but I do leave the silica packet in the tub and give the MaxiSame powder a good stir around every so often. For those people saying there isn't much powder in the container, it is sold by weight not volume. It's not a miracle cure but I do think that it is giving me a bit more time with my dog as I originally didn't think she'd get past Christmas. The only negative is that it is a shame the company doesn't offer a trial size for people to try it out as it is an expensive purchase.

I bought this product after my 17yr old Jack Russells blood test showed up very high liver count levels. It helped him a lot for the first 5-6 weeks and then he refused to eat anything with the powder in it. I had milk thistle drops that I was giving him with this product which he didn't mind taking. This is a good product and while he was taking it he was a different person, it started working within a few days. If you are anything like me, and would do anything for your child, then this product is a must, even just as an every day supplement. Sadly he stopped eating over Christmas while I was away on a family emergency and he became very weak and never recovered. He was put to sleep on the 10/01/25 as the liver damage was too far along. Hope this helps and that this product can buy you a bit more time with your beloved pet child.

Was a great idea, BUT after nine months it clearly isn't working for my dog. So back to the more expensive Denamarin for us, and back to fighting to get my furry fatso to take tablets!

After a harrowing year in which one of our dogs endured no less than four surgical procedures, we searched for a supplement that would address his persistently elevated liver enzymes. We purchased the maxxipaws maxxiSAMe Advanced SAM-e Powder Supplement in the hope that it would offer the support needed to help get his health back on track. 💔 The only pro I can find to outline is that the supplement proved to be palatable to a dog who was feeling less than enthusiastic about eating. Frankly, though, the product did nothing. We saw absolutely no reduction in his liver enzyme levels, which was incredibly disappointing after investing both hope and money into this treatment plan. The situation was made worse when our dog developed an allergy. One of the things we needed to do as a matter of urgency was check all the ingredients in his current supplements. We reached out to the company's customer service team to ask a simple, but critical, question: whether the product contained corn or any corn-derived ingredients. They did not even answer our e-mail. 😔 The total lack of response is disappointing. I can only conclude that ingredient sourcing is inconsistent or that the company did not want to or could not answer my question. When dealing with a pet's health, particularly allergy concerns, prompt and clear communication from a manufacturer is essential. This experience not only proved the product to be ineffective for our needs, but also revealed a significant and concerning failure in customer support. ❌ Based on our experience - zero efficacy and zero customer care therefore zero value for money - we cannot recommend this product. It provided no benefit for our dog's temporary liver enzyme elevation and the company left us hanging when we needed basic ingredient information. My dog's liver enzymes were subsequently addressed by dosing him with a high quality Chinese Herbal Supplement for pets, designed by a Canadian Veterinarian - proof of what can be achieved with properly formulated herbal and nutraceutical supplements.

Our old Labrador seemed to really benefit from maxxisame, it definitely helped her liver recover several times and helped her mobility and she liked the taste too. She has sadly just passed away now at 15 but we think this product has kept her going for a long time. Thank you maxxipaws.

Compro periodicamente questo integratore per la mia cagnolina di quasi 13 anni e devo dire che i risultati ed un miglioramento sono visibili anche dalle analisi del sangue. Questo prodotto è ottimo per mantenere giusti valori epatici e per le articolazioni Io lo metto nella dieta casalinga della mia cagnolina sulla base del suo peso come riportato sulla scatola.

Mon bichon âgé de 13 ans commençait à perdre la tête et était devenu complètement sourd. Il n'avait plus de joie de vivre et se renfermait de plus en plus sur lui-même. Cela fait un peu plus d'un mois qu'il prend ce traitement et il a radicalement changé. Il est joueur, il communique à nouveau et réentend certains sons. Il a rajeuni de quelques années !!! pourvu que cela dure dans le temps...

A mi perro le vá fantástico. Tiene problemas con el higado y lo necessita para vivir bien.

Update 10/15/2025: Hi there, me again. Now that it is 8 years later, Barney's adopted little brother Maximus is well into his senior years. He's in great shape for his age, which we estimate to be around 13 years (he's a rescue pittie), but he's started showing some signs of cognitive decline - restlessness, pacing, and panting, especially at night. We are managing his relatively mild arthritis stiffness with meds from our vet, thinking that's why he was so agitated, but the cognitive symptoms persisted. That's when I remembered how much this supplement helped our Barney all those years ago. We've been loyal to the Maxxi brand this whole time - Max gets the Omega oil and MaxxiDigest on his food daily to help with his coat and tummy (ya boy gets some serious diarrhea and gas that'll knock you out without it) - so I can't believe it took me this long to remember that MaxxiSAMe exists. Unlike Barney, Max gobbles this stuff right up with his food, no weird cheese sushi roll required. Thank you, MaxxiPaws, for continuing to put out a quality product. ---- Final Barney update 5/24/2017: This will be my final update to this review, as we unfortunately had to say goodbye to our wonderful dog Barney last week after his slow onset of degenerative myleopathy had progressed too far. I cannot say enough good things about the MaxxiDog company as they helped us find solutions to make Barney's last year+ as comfortable and happy as it could be. I truly believe that the MaxxiSAMe product had a positive effect for Barney and was key in making his last time with us a happy one, as it really seemed to help mitigate his symptoms of Canine Cognitive Dysfunction (CCD). I have changed my review to five stars to reflect this. Please continue reading below for the original review, and the other updates on how we ended up using the product. (Spoiler: The most effective way to get Barney to eat it was to do two small pumps of MaxxiOmega oil with it to make a paste, and then put the paste in American cheese like a weird little sushi roll! He never turned his nose up at this option.) Thank you again to the MaxxiDog company for your excellent product and wonderful customer service. ---- (Original review:) My dog Barney is well into his golden years and has is showing some pretty strong signs of canine cognitive dysfunction (CCD; basically, doggie dementia) such as night waking/panting, getting lost or stuck in corners, licking, digging at the floor, and fecal incontinence. So, I powered up the ol' computer and did some research. It turns out there isn't a ton you can do for it once they've got it, but there are supplements that can help manage some of the symptoms and keep it from progressing as quickly. Enter: SAMe and choline. These two seemed to pop up the most in my searches but my head was spinning about what product to buy. Well, this MaxxiSAMe stuff handily has both! Awesome! Now, a little bit about Barney - Barney has been anywhere from 77 to 90 pounds since I've known him. This dog LOVES to eat. He's not picky, either - he eats 'yard treats' (if you catch my drift) regularly, for goodness sake. He once ate a raw zucchini off the floor (and immediately threw it up, but that's beside the point). Now that we've been more careful about his portion sizes he acts like we're starving him to death (I assure you, we are not) and scavenges even more. But as soon as I put this stuff on his food, Barney went on a hunger strike. He will NOT touch the stuff. It's crazy. I even tried burying cheese in his bowl thinking he'd at least eat his way down to the cheese - NOPE. Not interested. I really wish this came in pill form. I've resorted to trying to squish the dosage up in cheese and give it to him that way, which is pretty difficult since he is on the highest dosage (1 tsp per dosage, twice a day), and the supplement needs to be inside the cheese for him to eat it. I have made some messes. I think my next attempt may involve deli meat since that won't fall apart like cheese slices... though now I have visions of Barney biting into the powder ball in the meat and causing an explosion. He's only had his full dosage(ish... the part that hasn't scattered out of the cheese all over the floor anyway) for a day or two. If I notice some improvement or come up with a better method of administration, I'll absolutely come back and edit my review. I really, really want to love this product. But for now, I give it 5 stars in theory and Barney gives it a 1 star in taste so we'll compromise and call it a 3. ---- UPDATE 4/28/2016: We went through two jars of this stuff, and multiple administration methods (since adding it straight to dry food was NOT an option). First I'll talk about the effects it has had on him, and then I will talk about how we've been giving it to him. EFFECTS: After giving him two jars of this, I didn't buy a third. After a few days of not being on it, his CCD symptoms increased fairly dramatically - walking around panting/whining at night, getting lost in corners, pooing inside, etc. He was still doing some of those things SOMETIMES, so it's possible that the timing of his symptoms was coincidental with stopping the MaxxiSAMe. However, I had forgotten just how bad his symptoms used to be, especially the night symptoms - we were all sleeping very terribly for a few days there. So I bought another jar hoping it would help him, and I think it has. We all slept through the night better the last couple of nights, anyway! This is why I've upped my rating to 4 stars (was previously 3). ADMINISTRATION: Oh boy. Well, the folks at MaxxiSAMe were kind enough to respond to my review in both email form and comment form (below) and include some ideas for getting him to take it, which is super awesome of them. Here is what we've tried, and what has and hasn't worked - 1. Paste method: Add a small amount of water to make a thick paste. Give to dog like treat. This worked for maybe a couple of weeks, and now he just turns his nose away from it when I try to give it to him this way. The MaxxiSAMe folks also suggested mixing it with something he likes, but I don't think this would work, for reasons I'll get to in a moment. 2. Soft food method: Barney was on meds that made his stomach upset for a while, so to get him to eat, I would add warm water to his dry kibble food to make it soft and appealing. I could add the MaxxiSAMe directly to the soft food and he'd eat it right up. *shrug* 3. Paste + cheese method: This is what we're doing now. I add a VERY small amount of water to make a thick paste, which I form into a ball with my fingers. Then I smash cheese around it so that none (or at least very little) of the MaxxiSAMe ball is showing. If it is showing, he will not touch the stuff - or sometimes will sort of "work" at it to get the cheese off and spit the MaxxiSAMe out. This is why I don't think it would work to mix the paste with something he enjoys: he would still know the MaxxiSAMe is in there. I think this method would work better with lunch meat, but that's not something we normally have around the house, and it goes bad faster than cheese slices. This method would probably work okay with a PillPocket type treat that has a large enough pocket. So, in conclusion, Barney still thinks the stuff is super gross which makes administration a bit of an ordeal, but I have reason to believe it might be helping his CCD so that outweighs any difficulties in giving it to him. I do still wish it came in tablet form; I picture it being like Cosequin, where it's not a coated tablet but more of a compressed powder type tablet that can be broken if needed. Thanks again to the makers of this product for supplying such a high quality product, and for responding to reviews in such a thoughtful, detailed way! ---- UPDATE 6/17/2016: After my last update, the owners of MaxxiSAMe were not content that Barney still wasn't super into the stuff. They actually sent me a free bottle of their MaxxiOmega oil to try mixing that with the MaxxiSAMe, which is super awesome of them. Turns out, it totally worked. I mix his SAMe dosage with about a pump and a half of the oil, smear it on a piece of cheese and wrap the cheese sushi-style, and he gobbles it right up. He still won't QUITE eat it without cheese (though he acts like he MIGHT when I've offered it to him), but I at least don't have to try to smash the cheese all around it to hide every speck of the MaxxiSAMe. Thank you!!

Ganz tolles Mittel. Hat die Leberwerte meines Schatzes innerhalb von drei Wochen von über 1.100 auf 350 senken können🙏🏻.... Die Werte sind zwar immer noch zu hoch, ich hoffe jedoch, dass wir bei der nächsten Kontrolle dann im Normalbereich liegen. Ich habe das Pulver allerdings nicht über das Essen gegeben, sondern mit Wasser vermischt zu einer Paste direkt ins Mäulchen☺️